The use of information theory for the evaluation of biomarkers of aging and physiological age

The present work explores the application of information-theoretical measures, such as entropy and normalized mutual information, for research of biomarkers of aging. The use of information theory affords unique methodological advantages for the study of aging processes, as it allows evaluating non-linear relations between biological parameters, providing the precise quantitative strength of those relations, both for individual and multiple parameters, showing cumulative or synergistic effect. Here we illustrate those capabilities utilizing a dataset on heart disease, including diagnostic parameters routinely available to physicians. The use of information-theoretical methods, utilizing normalized mutual information, revealed the exact amount of information that various diagnostic parameters or their combinations contained about the persons’ age. Based on those exact informative values for the correlation of measured parameters with age, we constructed a diagnostic rule (a decision tree) to evaluate physiological age, as compared to chronological age. The present data illustrated that younger subjects suffering from heart disease showed characteristics of people of higher age (higher physiological age). Utilizing information-theoretical measures, with additional data, it may be possible to create further clinically applicable information-theory-based markers and models for the evaluation of physiological age, its relation to age-related diseases and its potential modifications by therapeutic interventions.

David Blokh, Ilia Stambler, “The use of information theory for the evaluation of biomarkers of aging and physiological age,” Mechanisms of Ageing and Development, 163, 23-29, 2017, doi: http://dx.doi.org/10.1016/j.mad.2017.01.003.

Books


Longevity Promotion: Multidisciplinary Perspectives


A History of Life-Extensionism in the Twentieth Century

Articles

Longevity Advocacy

The Tasks of Longevity Promotion: Science, Ethics and Public Policy - Potential presentation topics on longevity research

Position Paper: The Critical Need to Promote Research of Aging. Aging and Disease, 2015

The pursuit of longevity - The bringer of peace to the Middle East. Current Aging Science, 6, 25-31, 2014

Recognizing degenerative aging as a treatable medical condition: methodology and policy. Aging and Disease, 2017

Frequently Asked Questions on the Ethics of Lifespan and Healthspan Extension

Longevity Science

The application of information theory for the research of aging and aging-related diseases. Progress in Neurobiology, 2016

The use of information theory for the evaluation of biomarkers of aging and physiological age. Mechanisms of Ageing and Development, 2017

Hyperbaric oxygenation for resuscitation and therapy of elderly patients with cerebral and cardio-respiratory dysfunction. Frontiers In Bioscience, 2017

Estimation of Heterogeneity in Diagnostic Parameters of Age-related Diseases. Aging and Disease, 5, 218-225, 2014.

Information theoretical analysis of aging as a risk factor for heart disease. Aging and Disease, 6, 196-207, 2015

Applying information theory analysis for the solution of biomedical data processing problems. American Journal of Bioinformatics, 3 (1), 17-29, 2015

Stop Aging Disease! ICAD 2014. Aging and Disease, 6 (2), 76-94, 2015

The Historical Evolution of Evolutionary Theories of Aging

Potential Interventions to Ameliorate Degenerative Aging

Longevity History

Introduction to "A History of Life-Extensionism in the Twentieth Century"

Life-extensionism as a pursuit of constancy

Has aging ever been considered healthy? Frontiers in Genetics. Genetics of Aging, 6, 00202, 2015

The Legacy of Elie Metchnikoff

Longevity and the Jewish Tradition

Longevity and the Indian Tradition

Longevity in the Ancient Middle East and the Islamic Tradition

Longevity and the Christian Tradition

Life extension - a conservative enterprise? Some fin-de-siecle and early twentieth-century precursors of transhumanism. Journal of Evolution and Technology, 21, 13-26, 2010

The unexpected outcomes of anti-aging, rejuvenation and life extension studies: an origin of modern therapies. Rejuvenation Research, 17, 297-305, 2014

Heroism and Heroic Death in Nineteenth Century Literature

Reductionism and Holism in the History of Aging and Longevity Research: Does the Whole have Parts?

Aristotle on Life and Long Life